James Harden scored 29 points, Russell Westbrook added his second straight triple-double with 28 points, 13 assists and 10 rebounds and Houston sent New Orleans to its first 0-3 start since the 2016-17 season.
Westbrook hit two clutch free throws to give Houston the three-point lead with 6.1 seconds remaining. Josh Hart missed a 3 at the buzzer to give Houston the win.
Westbrook and Harden combined for 12 turnovers, with Harden leading the game with eight. Harden was 2 of 18 from the 3-point line and 8 for 29 from the field, but was 11 of 12 from the free throw line.
Brandon Ingram scored 35 points while adding a game-high 15 rebounds. Lonzo Ball had 18 points on 4-of-9 shooting from 3-point range.
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